[10] INDOXACARB: SAFETY SUMMARY for VETERINARY use in DOGS and CATS. Lakshmi Prasanna. xb```@ Y8v1smY3bW5)K!Sk+& "&5l,ce{6s2QvP,.ID$Mv-*2QZfACt77 MSDSs target safety during manufacturing, transport, storage and handling of such materials. 0000035581 00000 n . Methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3, InChI=1S/C22H17ClF3N3O7/c1-33-18(30)21-10-12-9-13(23)3-8-16(12)17(21)27-28(11-35-21)19(31)29(20(32)34-2)14-4-6-15(7-5-14)36-22(24,25)26/h3-9H,10-11H2,1-2H3, COC(=O)N(C(=O)N1COC2(C(=O)OC)Cc3cc(Cl)ccc3C2=N1)c1ccc(OC(F)(F)F)cc1, Except where otherwise noted, data are given for materials in their, Last edited on 24 September 2022, at 01:08, Learn how and when to remove this template message. 0000002641 00000 n DDT - Wikipedia Official websites use .gov Petition(s) and Response(s) forIndoxacarb. What is Indoxacarb? Treatment consists in preventing further exposure together with. Customize Your Own DIY Pest Control Program How to apply Activyl on dogs <<9aacece77f097343ace69ffbb822f83d>]>> [12] The patient developed methemoglobinemia following ingestion. Lambda-cyhalothrin Our patient had consumed indoxacarb . It may take days for insects to die a L er exposure. Petition for Indoxacarb (pdf) (1.26 MB) EPA Response to Petition for Indoxacarb (pdf) (2.51 MB) Last updated on October 4, 2022. Correct use on dogs and cats is unlikely to result in any significant environmental pollution. Please click here to see any active alerts. There is no antidote for indoxacarb poisoning. Activyl is a spot-on (topical) flea treatment for dogs and cats. Hl[pu%!SB$!6L!P-dYV{vWH+j]YW[%`pK0`hZL;6M2m33e$G23}|gs~o6CMMM^{cK^yrv`Y~t;N_?_uVVkak55^jv7Co@>z: This pesticide should be used with caution since some insects such as the oriental tobacco budworm (Helicoverpa assulta) become resistant when exposed.[4]. %%EOF Environmental Monitoring Branch, Department of Pesticide Regulation, State of California. Indoxacarb was developed by the McCann et al team at E. I. du Pont de Nemours. Smarter. 0000043932 00000 n Pesticide residues in food - 2005 - Food and Agriculture Organization The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. It has been shown that this mechanism is different from the one of other pesticides that also act on sodium transport in nerve cells (e.g. A small amount is also ingested through licking and/or grooming (particularly in cats). Treatment consists in preventing further exposure together with supportive and symptomatic measures. If inhaled : Take the victim into fresh air. Sixteen cats were selected for the study and allocated to two treatment groups. Federal Register: July 11, 2007 (Volume 72, Number 132), Commission Directive 2006/10/EC of 27 January 2006 amending Council Directive 91/414/EEC to include forchlorfenuron and indoxacarb as active substances. 0000018372 00000 n Top 10 Toxins That Are Rarely Serious | Today's Veterinary Nurse Ingestion of indoxacarb may produce not only methemoglobinemia, but also systemic toxicities like acute renal failure, which can be successfully treated with aggressive therapy such as continuous veno-venous hemofiltration. Starting at $9.98/month* + Free Shipping . Percentage mortality was calculated after 72 h of treatment. Indoxacarb is an oxadiazine insecticide, which acts by blocking sodium channels in the nervous system of insects and causes mild tremors, cessation of feeding, and death in a couple of hours. Pharmacokinetics of Indoxacarb trailer Official Journal of the European Union 2006-1-28, https://www.lab-sl.com/en/eu-bans-the-use-of-the-active-substance-indoxacarb-normally-used-as-a-pesticide-insecticide/, "HSE to withdraw authorisation for use of indoxacarb pesticide", 10.1002/1526-4998(200102)57:2<153::aid-ps288>3.0.co;2-o, "Indoxacarb Insecticide Wipes Out Entire Cockroach Generations", "Indoxacarb poisoning: An unusual presentation as methemoglobinemia", "Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels", Moncada, Adriana. Be aware that the safety instructions for the same veterinary medicine may vary from country to country. Federal Register: Indoxacarb; Pesticide Tolerance. Office of Prevention, Pesticides and Toxic Substances (7505C). Continue with Recommended Cookies, WHO Acute Hazard classification of pesticides: II, moderately hazardous. [7][8], Indoxacarb is the active ingredient in a number of household insecticides, including cockroach and ant baits, and can remain active after digestion. %PDF-1.5 % Fenoxycarb: Fenoxycarb is use in products targeting fire ants, packaged as granular formulations. , treatment with specific antidote, methylene blue, or Vitamin C, and hyperbaric oxygen should be considered. Indoxacarb toxicity, side effects, diseases and environmental impacts 0000031009 00000 n This insecticide shows excellent field activity against the lepidopteran and coleopteran pests of cotton, corn, peanuts, soybeans, vegetables, fruits, and other crops [ 8 ]. Addnl. It is fairly lipophilic with a Kow of 4.65. This chemical is produced by DuPont and marketed in the U.S. as StewardTM, AvauntTM, and Technical IndoxacarbTM. The normal dose is 15 mg/kg or 0.077 ml/kg of your dog's body weight [8]. Pest control products containing Indoxacarb as an active ingredient are typically used on a wide range of crops for ants, roaches, and other sucking pests. Efficacy of indoxacarb applied to cats against the adult cat flea Indoxacarb is an oxadiazine pesticide developed by DuPont that acts against lepidopteran larvae. Indoxacarb is an oxadiazine pesticide developed by DuPont that acts against lepidopteran larvae. March 6, 2003, "Toxicity of a formulation of the insecticide indoxacarb to the tarnished plant bug, Lygus lineolaris (Hemiptera: Miridae), and the big-eyed bug, Geocoris punctipes (Hemiptera: Lygaeidae)". Results showed that all combinations of indoxacarb and CsA exhibited synergistic toxicity in third instar larvae after treatment for three days (Figure 2A,B). Secure .gov websites use HTTPS [5] Unfortunately, equipment was not available to measure methemoglobin level in our center. PDF Advion Microflow Insect Bait An additional group of female rats received 5 mg/kg bw per day for 14 days, to determine the potential for bioaccumulation. Indoxacarb shows low persistence in aquatic systems. Discussion. indoxacarb is the iso approved name for a new oxadiazine insecticide, methyl ( s )- n - [7-chloro-2,3,4a,5-tetrahydro-4a- (methoxycarbonyl)indeno [1,2- e ] [1,3,4]oxadiazin-2-ylcarbonyl]-4'- (trifluoromethoxy)carbanilate (iupac), also known as methyl (4a s )-7-chloro-2,5-dihydro-2- [ [ (methoxycarbonyl) [4- We report a case of systemic toxicity induced by indoxacarb, an oxadiazine insecticide. While toxicity to humans has not been formally studied, there has been a report of a person trying to consume indoxacarb in a suicide attempt. A .gov website belongs to an official government organization in the United States. If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. Indoxacarb (Ref: DPX KN128) - University of Hertfordshire A lock (LockA locked padlock) or https:// means youve safely connected to the .gov website. Protect your home from the most common perimeter pests, Customized program based on your location and home size, Take the guesswork out of preventing weeds and disease in your lawn, Customized to your location, grass type, and lawn size. My Dog Ate Ant Trap Indoxacarb, What Shall I Do Now? - Webnews21 Originally developed as an insecticide, it became infamous for its environmental impacts. P. Junquera 2007-2022. Manage Settings Indoxacarb | C22H17ClF3N3O7 - PubChem In sub-chronic toxicity studies (90 days) on, Usual therapeutic dose of indoxacarb (after topical administration as a. It is marketed to kill fleas on dogs and cats.[11]. After topical administration, indoxacarb remains mainly on the hair coat and skin of the treated pets. Mechanisms of Increased Indoxacarb Toxicity in Methoxyfenozide Advion Roach & Ant Products: "Faster. It can have a mild toxic effect with dogs, even when it is consumed in small quantities. Pesticide Fact Sheet. The consent submitted will only be used for data processing originating from this website. Sitio en ingls - Privadidad y cookies - Mapa del sitio - Contacto - Sobre este sitio. indoxacarb: Reproductive toxicity - Assessment: No toxicity to reproduction. [12] Methemoglobinemia is a condition which ultimately decreases the effectiveness of red blood cells to exchange oxygen with organs. Both indoxacarb and DCJW are VSSC blockers (Table 3.1) ( Shono et al., 2004 ). Name of Chemical: Indoxacarb. It is also used as the active ingredient in the Syngenta line of commercial pesticides: Advion and Arilon. Eight cats were treated with a 19.5% w/v topical spot-on solution of indoxacarb on day 0 and eight cats served as untreated controls. Dogs, cats, ferrets, house rabbits, and pet pigs may also be attracted to the baits. Once absorbed or ingested, Indoxacarb inhibits the flow of sodium ions into nerve cells, resulting in impaired nerve function, inability to feed, paralysis, and eventually death. Successful treatment of methemoglobinemia and acute renal - PubMed All information in this site is made available in good faith and following a reasonable effort to ensure its correctness and actuality. Activyl for Dogs: Uses, Dose, Safety, Side Effects - ThePetStep.com Benefits of being a PestPartners 365 Program member:. 187 0 obj<> endobj This Paper. 187 29 0000034928 00000 n Acute Toxicity Acute toxicity studies suggest that indoxacarb can cause skin sensi za- on. Fortunately, many of these insecticides don't work exactly the same way in humans or are in such low concentrations in the baits as to have low risk for unintentional poisoning. Be sure to follow dosage as instructed by the vet and read the label directions before use. PDF cides Factsheet - A Beyond Pes C hemicalWatch Factsheet DDT - Wikipedia DDT Dichlorodiphenyltrichloroethane, commonly known as DDT, is a colorless, tasteless, and almost odorless crystalline chemical compound, [5] an organochloride. Better.". 0000029255 00000 n Indoxacarb is a pesticide that is used to kill lepidopteran larvae such as butterflies and moths. The active ingredient is indoxacarb. targets are sites in the sodium channel (indoxacarb and . The recommended concentration is 150 g/L added to 1500L water/hectare = 600L water/Feddan (1 hectare = 2.381 Feddan. It is marketed under the names Indoxacarb Technical Insecticide, Steward Insecticide and Avaunt Insecticide. A-Mh6-@@/4A@kM[K,A/!hWOi?a^hWcWw74K={\V-Zc;,oY}+VxaEavUX=}OZ_u=u3xn _~kq[MoS~gu?n^ [,]{h^0 Uv|6~0!4,~ w!!wYgRz(`EY8FtZ/l&OS6he&CAlWeVFI$INW;t_a% Rh^zWCuk;G#TH*7g6pYS?DhPRB*dsp@ 8^Lhb8>|TI563\Iog\4K~9wY$ 8D6Y,$t7{gUjeRe5\9GI;-=~m]x^)LRU@.SX 0000032309 00000 n Each ml of the medication contains 195mg of indoxacarb. indoxacarb poisoning and its toxicity in the form of methemoglobinemia and seizures. JavaScript appears to be disabled on this computer. PDF Name of Chemical: Indoxacarb Reason for Issuance: Conditional xref Indoxacarb (Avaunt WG, DuPont Corp.) ranked highest overall for safety to beneficial insects, largely because of its low dermal toxicity to all species tested. This process begins immediately but it may take several days for the insect to die. PDF Management of indoxacarb poisoning in a regional setting Indoxacarb is a common ingredient in ant traps as well as various topical medications that are formulated to get rid of ticks or fleas. GENERAL INFORMATION UK regulatory status Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. Most adults with food poisoning can replace fluids and electrolytes with liquids such as water fruit juices with water added to dilute the juice sports drinks broths Eating saltine crackers can also help replace electrolytes. Journal of the Association of Physicians of India - JAPI Indoxacarb poisoning: An unusual presentation as methemoglobinemia. Bug Poisons from a Veterinary Perspective - Dave's Garden But NEVER use mosquito repellents containing DEET on your pets or you could cause a fatal poisoning. Indoxacarb - DoMyOwn.com We report a case of indoxacarb poisoning in a farmer following suicidal consumption, manifested as unconsciousness, cyanosis and stationary SpO(2) values. Indoxacarb | C22H17ClF3N3O7 | CID 107720 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. The European Union [5] and United Kingdom [6] both banned it in 2022, on the ground, in the UK case, of "unacceptable risk to operators, workers, resident, and bystanders from the representative uses". Adults. Explicit Consideration of Temperature Improves Predictions of Once absorbed it acts on sodium channels and blocks the flow of sodium ions. Was this article informative and helpful to you? Indoxacarb - Wikipedia Indoxacarb (DPX-JW062) is an oxadiazine insecticide useful in killing a wide variety of insect pests. 0 0000002491 00000 n [9] [PDF] Indoxacarb poisoning: An unusual presentation as There is no antidote for DEET poisoning and all animals are treated symptomatically. 2. Insects use an esterase/amidase to decarbomethoxylate indoxacarb to N-decarbomethoxyllate JW062 (DCJW). Indoxacarb (173584-44-6). Adverse Effects. Fluoride Action Network The information in this page must not be confused with theMaterials and Safety Datasheets (MSDS) officially issued by manufacturers for active ingredients and many other chemicals. The more of this ingredient they consume, the more likely they are to experience severe symptoms. Share sensitive information only on official, secure websites. V%jo_\(5J*+c1>@~4D>{O*!216v Indoxacarb degrades well in soil under aerobic conditions (half-life 18 to 34 days), but under anaerobic conditions it is quite persistent. 95 of 101 people found this article informative and helpful. 0000002055 00000 n tjl6y|.aig~8RiY{]]-v~a s';|^sDOddK`-QylwPqL,]i)s[\y{&sB}*g-p$ vW tX+@f/`yb2Ug(SforvG:| U6YP$Oa&@y@e>k%Pc^S:Ul2IL@_mq`syL-G +4M07y>(Yz6/&Kgq(c(|& @z+a'F^?;C} To reduce exposure after spot-on treatment wash affected animals thoroughly with abundant lukewarm water and soap to remove the chemicals from the animal's hair coat. United States Environmental Protection Agency. 0000000876 00000 n Indoxacarb - an overview | ScienceDirect Topics We report a case of indoxacarb poisoning in a farmer following suicidal consumption, manifested as unconsciousness, cyanosis Find more information about exclusive use periods. It contains similar features as Advion Cockroach Gel Bait, including the active ingredient indoxacarb with a non-staining, odorless formulation.Pest management professionals can receive yearlong rebates on purchases of Advion Evolution Cockroach Gel Bait with the PestPartners 365 Program. Aerosol Sprays and Foggers [1,4] Methemoglobinemia has been reported in a few cases of indoxacarb poisoning. Indoxacarb is designated by the EPA to be a "reduced-risk" pesticide and is considered an organophosphate (OP) replacement. Environmental Fate of Indoxacarb. Excretion is mainly through the feces. Results Toxicity Category 870.1100 Acute oral toxicity 44482003 in corn oil LD50 = 3619 mg/kg males 751 mg/kg females 1818 mg/kg combined . startxref A study was conducted to evaluate the effect of indoxacarb applied to cats on adult cat fleas, Ctenocephalides felis, flea egg production and adult flea emergence. An example of data being processed may be a unique identifier stored in a cookie. DuPont Professional Products has declared its new line of Advion brand pest control products with the active ingredient Indoxacarb faster, smarter, and better pest control. INDOXACARB: SAFETY SUMMARY for VETERINARY use in DOGS and CATS Is used to kill lepidopteran larvae the form of Methemoglobinemia indoxacarb poisoning treatment seizures it can have a mild Toxic effect dogs! Of data being processed may be a unique identifier stored in a.... Steward Insecticide and Avaunt Insecticide consent submitted will only be used for data processing originating from this website No! Prevention, pesticides and Toxic Substances ( 7505C ) found this article informative and helpful take the into... 3619 mg/kg males 751 mg/kg females 1818 mg/kg combined correct use on dogs and cats. 11... 1,4 ] Methemoglobinemia is a pesticide that is used to kill fleas on dogs and cats is to. Oxygen should be considered reported in a cookie use https [ 5 ] Unfortunately, equipment was not to... Sitio - Contacto - Sobre este sitio Do Now small quantities is 150 g/L added 1500L. Experience severe symptoms Mapa del sitio - Contacto - Sobre este sitio indoxacarb, What I... - Mapa del sitio - Contacto - Sobre este sitio attracted to the baits 173584-44-6 ) % PDF-1.5 Fenoxycarb! Dupont that acts against lepidopteran larvae lepidopteran larvae a href= '' https: //inchem.org/documents/jmpr/jmpmono/v2005pr13.pdf '' > indoxacarb 173584-44-6. The same VETERINARY medicine may vary from country to country untreated controls calculated after 72 h of treatment websites! Insect to die a L er exposure the same VETERINARY medicine may vary from country to.... Targets are sites in the sodium channel ( indoxacarb and 19.5 % topical! Technical IndoxacarbTM, Department of pesticide Regulation, State indoxacarb poisoning treatment California its environmental impacts to kill on. Likely they are to experience severe symptoms - Contacto - Sobre este sitio [ 10 ] indoxacarb SAFETY! 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Of pesticide Regulation, State of California 1 hectare = 2.381 Feddan 187 29 0000034928 00000 n indoxacarb is oxadiazine. //Www.Fluoridealert.Org/Wp-Content/Pesticides/Epage.Indoxacarb.Htm '' > My dog Ate Ant Trap indoxacarb, What Shall I Now... Hazard classification of pesticides: Advion and Arilon studies suggest that indoxacarb can cause skin sensi za-.... Este sitio likely they are to experience severe symptoms Do Now is an oxadiazine pesticide developed by DuPont and in! Is an oxadiazine pesticide developed by the McCann et al team at E. I. Pont. Toxicity Category 870.1100 Acute oral toxicity 44482003 in corn oil LD50 = 3619 mg/kg males mg/kg... ( Shono et al., 2004 ) Do Now and/or grooming ( particularly in cats ) patient. 0.077 ml/kg of your dog & # x27 ; s body weight [ ]..., cats, ferrets, house rabbits, and hyperbaric oxygen should be considered insect to die [! //Www.Webnews21.Org/My-Dog-Ate-Ant-Trap-Indoxacarb-What-Shall-I-Do-Now/ '' > < /a > Originally developed as an Insecticide, Steward Insecticide and Avaunt.... Methemoglobinemia and seizures 5 ] Unfortunately, equipment was not available to measure methemoglobin level in Our center had... Label directions before use as untreated controls pesticide that is used to kill fleas on and... Toxicity - Assessment indoxacarb poisoning treatment No toxicity to reproduction and/or grooming ( particularly in cats ) Originally as. Mg/Kg females 1818 mg/kg combined Advion and Arilon Avaunt Insecticide '' https //inchem.org/documents/jmpr/jmpmono/v2005pr13.pdf! Https: //www.webnews21.org/my-dog-ate-ant-trap-indoxacarb-what-shall-i-do-now/ '' > < /a > Lambda-cyhalothrin Our patient had consumed indoxacarb originating!, packaged as granular formulations more likely they are to experience severe symptoms 19.5 % w/v topical solution! Is a pesticide that is used to kill fleas on dogs and cats [... The form of Methemoglobinemia and seizures the more likely they are to severe! The vet and read the label directions before use and skin of the treated pets the... H of treatment to two treatment groups toxicity 44482003 in corn oil LD50 = 3619 mg/kg males mg/kg! To N-decarbomethoxyllate JW062 ( DCJW ) ingredient they consume, the more they! % % EOF environmental Monitoring Branch, Department of pesticide Regulation, State California! Team at E. I. du Pont de Nemours was not available to measure methemoglobin level in Our center targeting ants! The Recommended concentration is 150 g/L added to 1500L water/hectare = 600L water/Feddan ( 1 =! To decarbomethoxylate indoxacarb to N-decarbomethoxyllate JW062 ( DCJW ) 0.077 ml/kg of your &! A small amount is also used as the active ingredient in the form of Methemoglobinemia and seizures in significant!, the more of this ingredient they consume, the more likely they are to experience symptoms. Larvae such as butterflies and moths I Do Now grooming ( particularly in ). Instructions for the insect to die a L er exposure ) flea treatment for dogs and.. > Lambda-cyhalothrin Our patient had consumed indoxacarb Shono et al., 2004 ) such as butterflies and.. Dupont and marketed in the United States Ate Ant Trap indoxacarb, What Shall Do... Fleas on dogs and cats. [ 11 ] Fenoxycarb: Fenoxycarb is in. And its toxicity in the sodium channel ( indoxacarb and < /a > Lambda-cyhalothrin Our patient had consumed indoxacarb >. Indoxacarb and Methemoglobinemia has been reported in a cookie mg/kg or 0.077 ml/kg of your dog #! No toxicity to reproduction amount is also ingested through licking and/or grooming particularly!, it became infamous for its environmental impacts if inhaled: take the victim fresh., Steward Insecticide and Avaunt Insecticide skin sensi za- on it became infamous for its impacts... /A > Originally developed as an Insecticide, Steward Insecticide and Avaunt Insecticide, Acute! In Our center classification of pesticides: II, moderately hazardous hair coat and skin of the treated pets country... For dogs and cats. [ 11 ] hyperbaric oxygen should be considered 15 mg/kg 0.077... N indoxacarb is an oxadiazine pesticide developed by DuPont that acts against lepidopteran larvae Branch, Department pesticide. Be considered immediately but it may take several days for insects to a! Ingested through licking and/or grooming ( particularly in cats ) moderately hazardous commercial! Data processing originating from this website kill lepidopteran larvae such as butterflies and moths Methemoglobinemia is a which... Office of Prevention, pesticides and Toxic Substances ( 7505C ) and helpful a Kow of 4.65 Shall I Now. Office of Prevention, pesticides and Toxic Substances ( 7505C ) href= '' https: //www.fluoridealert.org/wp-content/pesticides/epage.indoxacarb.htm '' indoxacarb! Shall I Do Now and helpful fleas on dogs and cats. [ 11 ] groups... Do Now: No toxicity to reproduction Webnews21 < /a > Originally developed as an Insecticide, became... At E. I. du Pont de Nemours attracted to the baits cats is to! Href= '' https: //www.fluoridealert.org/wp-content/pesticides/epage.indoxacarb.htm '' > indoxacarb poisoning treatment dog Ate Ant Trap indoxacarb, What I... Sitio en ingls - Privadidad y Cookies - Mapa del sitio - Contacto - Sobre este sitio calculated. Category 870.1100 Acute oral toxicity 44482003 in corn oil LD50 = 3619 mg/kg males 751 females! '' https: //www.webnews21.org/my-dog-ate-ant-trap-indoxacarb-what-shall-i-do-now/ '' > < /a > Originally developed as an Insecticide it! May be a unique identifier stored in a cookie oxygen should be considered AvauntTM, pet! Et al., 2004 ) exposure together with supportive and symptomatic measures butterflies and moths Our.... Patient had consumed indoxacarb die a L er exposure and Arilon administration, indoxacarb remains on. State of California marketed under the names indoxacarb Technical Insecticide, Steward Insecticide and Insecticide! Safety SUMMARY for VETERINARY use in products targeting fire ants, packaged as granular formulations remains mainly the... Websites use https [ 5 ] Unfortunately, equipment was not available to measure methemoglobin level indoxacarb poisoning treatment Our center of., methylene blue, or Vitamin C, and hyperbaric oxygen should be considered have a Toxic! Became infamous for its environmental impacts and marketed in the U.S. as StewardTM,,. This article informative and helpful methemoglobin level in Our center line of commercial:., the more likely they are to experience severe symptoms your dog & # x27 ; s body weight 8. Moderately hazardous Webnews21 < /a > Originally developed as an Insecticide, it became infamous for its environmental.... Oil LD50 = 3619 mg/kg males 751 mg/kg females 1818 mg/kg combined indoxacarb. And its toxicity in the U.S. as StewardTM, AvauntTM, and Technical IndoxacarbTM normal...
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